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Dr. Julie  Pollock
Dr. Julie Pollock
Assistant Professor of Chemistry
Profile

My lab utilizes chemical biology techniques, biochemical methods, and organic synthesis to understand breast cancer and lung cancer development and progression. In particular, we are interested in nuclear receptor function, phosphorylation signaling pathways, and the link between cancer and inflammation.

Grants and Fellowships

2017: Jeffress Trust Award in Interdisciplinary Research

2016: Mary Louise Andrews Award for Cancer Research, Virginia Academy of Sciences

2013-2014: NIH Postdoctoral Fellowship in Endocrine, Developmental, and Reproductive Toxicology

2011: ACS Biological Division Travel Grant

Presentations

Strategies towards ligand-selective modulation of nuclear receptors. Institute for Structural Biology, Drug Discovery and Development. Virginia Commonwealth University, Richmond, VA, May 2016.

Pollock, J. A.; Saijo, K.; Glass, C. K.; Katzenellenbogen, J. A. Characterization of Estrogen Receptor Ligands in Microglia-Mediated Inflammation. Interdisciplinary Environmental Toxicology Seminar Series, University of Illinois, Urbana, IL, February 2014.

Pollock, J. A.; McCafferty, D.G. LSD1: Inhibition and Implications in Breast Cancer. Duke University Breast Cancer Forum, Durham, NC, September 2011.

Selected Publications
Articles

Hughes, L.B.*; Labban, N.*; Conway, G.E.*; Pollock, J.A.; Leopold, M.C. “Adaptable xerogel-layered amperometric biosensor platforms on wire electrodes for clinically relevant measurements.” Sensors 2019, 19, 2584. doi: 10.3390/s19112584.

Park, H.*; McEachon, J.D.*, Pollock, J.A. “Synthesis and characterization of hydrogen peroxide activated estrogen receptor beta ligands.” Bioorg. Med. Chem. 2019, 27, 2075-2082. doi: 10.1016/j.bmc.2019.04.003 Graphical abstract chosen for cover

Labban, N.*; Wayu, M.B.; Steele, C.M.*; Munoz, T.S.*; Pollock, J.A.; Case, W.S.; Leopold, M.C.“First generation amperometric biosensing of galactose with xerogel-carbon nanotube layer-by-layer assemblies.” Nanomaterials 2019, 9, 42. doi: 10.3390/nano9010042

Wayu, M.B.; Pannell, M.J.*; Labban, N.*; Case, W.S.; Pollock, J.A.; Leopold, M.C.“Functionalized carbon nanotube adsorption interfaces for electron transfer studies of galactose oxidase.” Bioelectrochemistry 2019, 125, 116-126. doi: 10.1016/j.bioelechem.2018.10.003

Pollock, J.A.; Sharma, N.; Ippagunta, S.K.; Redecke, V.; Häcker, H.; Katzenellenbogen, J.A.“Triaryl pyrazole Toll-like receptor signaling inhibitors: Structure-activity relationships governing pan- and selective signaling inhibitors.” ChemMedChem 2018, 13, 2208-2216. doi: 10.1002/cmdc.201800417

Newkirk, M.L.*; Rubenstein, K.J.*; Kim, J.Y.*; Labrecque, C.L.*; Airas, J.*; Taylor, C.A.*; Evans, H.D.*; McKoy, Q.*; Parish, C.A.; Pollock, J.A.“Analysis of MEMO1 binding specificity for ErbB2 using fluorescence polarization and molecular dynamics simulations.” Biochemistry 2018, 57, 5169-5181. doi: 10.1021/acs.biochem.8b00582

Ippagunta, S.K.; Pollock, J.A.; Sharma, N.; Lin, W.; Chen, T.; Tawaratsumida, K.; High, A.A.; Min, J.; Chen, Y.; Guy, R.K.; Redecke, V.; Katzenellenbogen, J.A.; Häcker, H. “Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.” Sci. Signal. 2018, 11(543), eaaq1077. doi:  10.1126/scisignal.aaq1077    

Christenson, J.L.; Butterfield, K.T.; Spoelstra, N.S.; Norris, J.D.; Josan, J.S.; Pollock, J.A.; McDonnell, D.P.; Katzenellenbogen, B.S.; Katzenellenbogen, J.A.; Richer, J.K. “MMTV-PyMT and derived Met-1 mouse mammary tumor cells as models for studying the role of the androgen receptor in triple-negative breast cancer progression.” Horm. Canc. 2017, 8(2), 69-77.

Pollock, J.A.; Wardell, S.E.; Parent, A.A.; Stagg, D.B.; Ellison, S.J.; Alley, H.M.; Chao, C.A.; Lawrence, S.A.; Stice, J.P.; Spasojevic, I.; Baker, J.G.; Kim, S.H.; McDonnell, D.P.; Katzenellenbogen, J.A.; Norris, J.D. “Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.” Nature: Chem. Biol. 2016, 12, 795-801.

Pollock, J.A.; Kim, S.H.; Katzenellenbogen, J.A. “Imidoyl dichlorides as new reagents for the rapid formation of 2-aminobenzimidazoles and related azoles.” Tetrahedron Lett. 2015, 26, 6097-6099.

Nwachukwu, J. C.; Srinivasan, S.; Bruno, N. E.; Parent, A. A.; Hughes, T. S.; Pollock, J. A.; Gjyshi, O.; Cavett, V.; Nowak, J.; Garcia-Ordonez, R. D.; Houtman, R.; Griffin, P. R.; Kojetin, D. J.; Katzenellenbogen, J. A.; Conkright, M. D.; Nettles,  K. W. “Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network.” eLife 2014, 3, e02057.

Pollock, J. A.; Larrea, M. D.; Jasper, J. S.; McDonnell, D. P.; McCafferty, D. G. “Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and independent manners.” ACS Chem. Biol. 2012, 7, 1221-1231.

Education
Ph.D., Duke University
Chemistry
Contact Information
C308 Gottwald Center for the Sciences
(804) 484-1578
(804) 287-1897 (Fax)
Areas of Expertise
Chemical Biology
Biochemistry
Organic Chemistry